SYNAPSE Lab

  • SYNAPSE Lab

    The Sensorimotor Neuroplasticity Research Lab (SYNAPSE) identifies and validates therapies that promote recovery of movement after spinal cord injury, multiple sclerosis, and stroke.
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    Research Spotlight: New Advances in Multiple Sclerosis Rehabilitation

    Ongoing Multiple Sclerosis (MS) research at Shirley Ryan AbilityLab aims to help patients improve their long-term outcomes and independence.
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    Our Projects

    Take a look at a few of the projects we work on everyday.

    Markerless Movement Analysis
    PROJECT TYPE: Gait, Biomechanics

    Research Project

    Acute Intermittent Hypoxia-primed myoelectric interface training
    PROJECT TYPE: Gait, Exergaming

    Research Project

    Acute Intermittent Hypoxia Initiated Motor Plasticity in MS
    PROJECT TYPE: Gait, Biomedical Engineering

    Research Project

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    Selected Publications

    Towards a Clinically Viable Measurement of Gait Quality: Construction and Validation of a Multiple Sclerosis Gait Deviation Index

    This study developed and validated the Multiple Sclerosis–specific Gait Deviation Index (MS-GDI), a clinically feasible measure of gait quality using low-cost, markerless motion capture with OpenCap. MS-GDI strongly correlated with established clinical measures of mobility and disability, while requiring minimal training and only minutes for analysis, supporting its potential as a scalable tool for routine rehabilitation assessment in persons with Multiple Sclerosis.

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    A research protocol to study the critical time window for rehabilitation after incomplete spinal cord injury: early vs. late locomotor training.

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    Effects of acute intermittent hypoxia on fatigue resistance and voluntary activation of leg muscles in intact humans.

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    Interested in joining us?

    Contact Our Lab