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The SYNAPSE Lab investigates therapies that promote sensorimotor neuroplasticity and recovery of movement after spinal cord injury, multiple sclerosis, and stroke. We focus on therapeutic techniques like acute intermittent hypoxia, neuromuscular and spinal cord stimulation, and pharmacological agents, delivered alongside task-specific motor training. We examine how these interventions alter sensorimotor function, from neurophysiology to motor behavior, using measurements like transcranial magnetic stimulation, high-density surface EMG, markerless motion capture, and quantitative assessment of strength, gait, and upper limb function. The objective is twofold: to identify the mechanisms through which these therapies act, and to test their efficacy in randomized controlled trials, with motor function and daily independence as the primary outcomes.

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Acute Intermittent Hypoxia Setup

Biodex Setup

Proprioception Device

Brainsight Neuronavigation and Transcranial Magnetic Stimulation (TMS)

TMS Participant Setup

Closed Desk Space

Open Desk Space

Intervention Space