Chicago

Defining trajectories of linguistic, cognitive-communicative and quality of life outcomes in aphasia

Posted By A. Domenighetti

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This is a collaborative project with Dr Allen Heinemann and Dr. Leora Cherney groups. For this project we will investigate the genetic association and interactions of Single Nucleotide Polymorphisms (SNPs) in genes that are associated with neuroplasticity (the brain's ability to reorganize itself by forming new neural connections) in post-stroke recovery. This study will investigate SNPs characterized in genes like Brain-derived neurotrophic factor (BDNF), Apolioprotein E (APOE), Insulin growth factor 1 (IGF1), Catechol-O-methyltransferase (COMT), Fibroblast growth factor 2 (FGF2), Vascular endothelial growth factor A (VEGF-A), and others. In particular, we seek to determine whether polymorphisms are associated, either independently or in combination, with language outcomes.

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