Andrea Domenighetti, PhD

Andrea Domenighetti, PhD

Research Scientist
Principal Investigator
Assistant Professor in PM&R at Northwestern University
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About Me

My current research includes the development, validation and implementation of preclinical and translational research relevant to striated muscles and movement disorders. In particular, I aim to identify new mechanisms relating to muscle tissue and muscle stem cell dysfunction in patients with brain injury, including cerebral palsy and stroke. Before joining the Rehabilitation Institute of Chicago (RIC) in 2015, my scientific work and interests were focused on mechanisms of cardiac hypertrophy, heart failure and skeletal muscle dysfunction using animal models, isolated cells analysis, video imaging, functional genomic and molecular biology. Prior to my appointment at RIC, I worked with colleagues in Cardiology and Orthopaedic Surgery at the University of California, in San Diego (UCSD) (2007-2015).


Shirley Ryan AbilityLab

26th Floor

355 East Erie

Chicago, IL 60611

Education & Training



    1994 - 1998
    Biology, University of Geneva - Switzerland
    1999 - 2004
    Physiology, University of Melbourne - Australia
    2004 - 2006
    Pharmacology & Toxicology, University of Lausanne - Switzerland

Recent Publications

Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.
Blondelle J, Shapiro P, Domenighetti AA, Lange S
doi: 10.1016/j.jmb.2017.02.012

Honors & Awards

  • Research fellowship
    Roche Research Foundation, 1999
  • International Postgraduate Research Scholarship (IPRS) and Melbourne International Research Scholarship (MIRS)
    The University of Melbourne, 2000
  • Young Researcher/Doctoral fellowship
    Swiss National Science Foundation, 2000
  • W.G. Nayler Prize
    International Society for Heart Research, 2002
  • Excellence Award in Cardiovascular Research
    Pfizer - Switzerland, 2007
  • Advanced postdoctoral fellowship
    Swiss National Science Foundation, 2006

Professional Affiliations

  • Fellow
    American Heart Association (AHA), 2007
  • Member
    Società Ticinese di Scienze Naturali (STSN), 2008
  • Member
    American Society for Cell Biology (ASCB), 2009
  • Member
    Orthopedic Research Society (ORS), 2015
  • Member
    Society For Muscle Biology, 2016
  • Member
    University of Geneva ex-alumni association, 2010

Research Interests

  • Skeletal muscles growth and (re)generation in children with cerebral palsy and stroke patients
  • Muscle stem cells biology
  • Epigenetic mechanisms of muscles homeostasis