Andrea Domenighetti, PhD

Andrea Domenighetti, PhD

Research Scientist and Principal Investigator

About Me

I have 15 years of post-graduate experience in developing, running and managing research projects in cellular, molecular & tissue biology for academic and healthcare Institutes worldwide. Over the years I have investigated molecular & cellular biomarkers and supported translational research approaches for the development of new therapeutics for chronic conditions, including cardiovascular, renal, neuromuscular and neurological. I use tools from molecular & cell biology, genetics and other experimental models, to identify new biomarkers and drugs that could support rehabilitation in patients with neurological or neuromuscular conditions. My lab is fully integrated into the Biologics Lab at the SRAlab and the PM&R Department at Northwestern University.


Shirley Ryan AbilityLab

26th Floor

355 East Erie

Chicago, IL 60611

Education & Training

    Education & Training


    1994 - 1998
    Biology, University of Geneva - Switzerland
    1999 - 2004
    Physiology, University of Melbourne - Australia
    2005 - 2006
    Pharmacology & Toxicology, University of Lausanne - Switzerland
    2007 - 2011
    Cardiology, University of California in San Diego - USA
    2011 - 2015
    Orthopedic Surgery, University of California in San Diego - USA

Recent Publications

Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy.
Domenighetti AA, Mathewson MA, Pichika R, Sibley LA, Zhao L, Chambers HG, Lieber RL
American journal of physiology. Cell physiology
doi: 10.1152/ajpcell.00351.2017
Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association.
Feingold B, Mahle WT, Auerbach S, Clemens P, Domenighetti AA, Jefferies JL, Judge DP, Lal AK, Markham LW, Parks WJ, Tsuda T, Wang PJ, Yoo SJ, American Heart Association Pediatric Heart Failure Committee of the Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular Radiology and Intervention; Council on Functional Genomics and Translational Biology; and Stroke Council
doi: 10.1161/CIR.0000000000000526
Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.
Blondelle J, Shapiro P, Domenighetti AA, Lange S
Journal of molecular biology
doi: 10.1016/j.jmb.2017.02.012

Honors & Awards

  • Research fellowship
    Roche Research Foundation, 1999
  • International Postgraduate Research Scholarship (IPRS) and Melbourne International Research Scholarship (MIRS)
    The University of Melbourne, 2000
  • Young Researcher/Doctoral fellowship
    Swiss National Science Foundation, 2000
  • W.G. Nayler Prize
    International Society for Heart Research, 2002
  • Excellence Award in Cardiovascular Research
    Pfizer - Switzerland, 2007
  • Advanced postdoctoral fellowship
    Swiss National Science Foundation, Switzerland, 2006
  • HALO "Heroes of Medicine" Awards
    For “discovering that an already approved drug used to treat a form of blood cancer may help treat or cure muscle contractures in children with cerebral palsy’, Chicago, IL, 2018

My Lab

Translational Biomedicine Lab

Our research group specializes in utilizing techniques from molecular and cell biology, genetics, and various experimental models. Our focus is on identifying new biomarkers and potential molecules to support rehabilitation in patients with neurological and neuromuscular conditions.

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