Muscle Physiology Lab

Three Distinct Cell Populations Express Extracellular Matrix Proteins and Increase in Number During Skeletal Muscle Fibrosis.

Tissue extracellular matrix provides structural support and creates unique environments for resident cells. However, the identities of cells responsible for creating specific ECM components have not been determined. In striated muscle, the identity of these cells becomes important in disease when ECM changes result in fibrosis and subsequent increased tissue stiffness and dysfunction. Here we describe a novel approach to isolate and identify cells that maintain the ECM in both healthy and…

Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy.

Reduced skeletal muscle satellite cell number alters muscle morphology after chronic stretch but allows limited serial sarcomere addition.