Smart Ankle-Foot Orthosis and Potential Muscle Growth Drug for Gait

Body

Many children with cerebral palsy (CP) experience challenges in balance and walking due to ankle impediments, including limited range of motion, reduced force, and stiffness. Previous research suggests that improving ankle strength may allow children with CP to engage in more physical activity. 

The purpose of this study is to determine the benefits of an at-home training protocol utilizing a smart ankle-foot orthosis (AFO) on walking outcomes in children with cerebral palsy (CP). Children enrolled in this study will use an activity monitor and smart AFO to practice exercise at home for 6 weeks. 

A subset of participants will also receive a dose of 5-azacitidine (AZA), an FDA-approved drug for pediatric oncology. AZA is not currently approved by the FDA for use in treating CP. Laboratory research has shown that AZA has the potential to aid in muscle growth and regeneration. It’s experimental, non FDA-approved use in this study is to investigate if targeting muscular deficits while also undergoing at-home smart AFO training further improves walking in children with CP. 

Body

This project is led by Megan O’Brien, PhD and Richard Lieber, PhD.

Body

This project is associated with the Max Näder Center for Rehabilitation Technologies and Outcomes Research and Building Advanced Cerebral Palsy Assistive Care Solutions (BACPACS) Centers.