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acute intermittent hypoxia

Clinical Trial

HANDS: A Multi-Center Clinical Trial to Evaluate the Effectiveness of Intermittent Hypoxia Therapy in Individuals with Spinal Cord Injury

IRB Protocol Number RSS00206247


Zev William Rymer


A study to investigate the effectiveness of daily acute intermittent hypoxia therapy (dAIH), coupled with a massed practice intervention or the use of high repetition training with the Rapael Glove, to improve upper-extremity function in individuals with chronic incomplete cervical SCI.

Who Can Participate

History of spinal cord injury between the levels of C3-T1.

At least 6 months since the onset of injury.

Classification of ASIA C or D.

No history of heart problems.

Not currently participating in another research study.

Not currently taking any antispasticity medications.


If you agree to take part in this research study, we will pay you the following for for your time and effort:

1. $40 for the initial screening visit

2. $40 for overnight oximetry assessment

3. $40 for each training session that you complete with intermittent hypoxia and/or training

4. $40 for each baseline and follow-up assessment session

If you visit the Shirley Ryan AbilityLab but are not able to complete the session that day, you will be paid $20 for your time and travel expenses. We expect each training session to last no more than 4 hours. However, if the session goes beyond 4 hours or if your total travel cost exceeds the reimbursement provided, you will be paid $10 for each additional hour. If you travel more than 20 miles to visit the laboratory, then you will be provided an additional $20 for each session you attend.

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