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Characterization and Clinical Trial of a Variable Friction Shoe, a new Paradigm of Reduced-Constraint Locomotor Therapy for People Exhibiting Foot Drop due to Stroke
To evaluate the effect of a variable friction shoe on walking in individuals with chronic stroke and foot drop.
Age Range
18+
Clinical Trial
Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic Spinal Cord Injury
Walking recovery is a key goal after spinal cord injury (SCI). While some patients experience spontaneous recovery due to preserved neural circuits, many struggle to achieve independent ambulation, and those who do often face persistent deficits. There is growing consensus that a single approach is insufficient to overcome these challenges, prompting the need for combined interventions.
Age Range
18-70
Clinical Trial
Multimodal Haptic Feedback for Plantar Sensory Substitution
Plantar sensation is crucial for gait, balance, and posture, and its loss contributes to movement disorders in conditions like multiple sclerosis, diabetes, stroke, and spinal cord injury. Current diagnostic methods use pressure sensor arrays to assess gait deficiencies, with wireless insole technology extending data collection beyond clinical settings. Building on these advances, we are investigating sensory substitution as a potential solution to restore lost plantar sensation and improve outcomes for affected individuals.
Age Range
18-85
Clinical Trial
Locomotor function following transcutaneous electrical spinal cord stimulation in individuals with hemiplegic stroke
Despite advances in stroke rehabilitation, more than two-thirds of the 7 million stroke survivors in the U.S. still struggle to walk independently in their communities. Most current therapies focus on stimulating the brain areas that control leg movement, yet many stroke survivors continue to face issues like poor coordination, spasticity, and muscle weakness. We propose a different approach—using electrical stimulation of the spinal cord to improve walking after stroke. This study is looking for persons who have had a stroke to determine if spinal stimulation helps improve walking ability.
Age Range
18-99
Clinical Trial
Help Us Learn About How You Use Your Arms In Daily Life
How does arm use in daily life change during the course of outpatient rehabilitation therapy? Data from wearable sensors and your feedback will help us learn how we can improve treatments to help people return to important daily activities.
Clinical Trial
Community Outreach Model of Education and Training on Communication: COMET-C
Age Range
21 - 99
Clinical Trial
MENTOR: Mindfulness, Exercise & Nutrition to Optimize Resilience
MENTOR is an 8-week introductory wellness
program designed to support your health – all
from the comfort of your home.
program designed to support your health – all
from the comfort of your home.
Age Range
18+
Clinical Trial
Robot-Assisted Upper Extremity Rehabilitation
The Shirley Ryan Ability Lab is conducting a research study on how robots can be used as rehabilitation tools.
Clinical Trial
Impact of Sensory Electrical Stimulation on Sensation and Tremor
The Shirley Ryan AbilityLab is studying the effect of nerve stimulation on proprioception (your sense of touch) and fine motor control in the hands, wrists, and arms to reduce tremor in patients with essential tremor. We are seeking healthy adults to participate as a comparison group.
Age Range
18-80
Clinical Trial
Learning and Evaluating Assistive Device Control with Autonomous Corrections
The Shirley Ryan Ability Lab is conducting a research study that will investigate a new approach for providing assistance for controlling an assistive device with limited interfaces for motor-impaired individuals.
Age Range
18 - 99
Clinical Trial
Effects of twice-daily dosing 4-AP on Functional Recovery after Spinal Cord Injury
Our studies aim to investigate potential Neuro-modulation Therapies with the help of an FDA approved drug in individuals with spinal cord injuries.
Age Range
18-85
Clinical Trial
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis (PREDICT)
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine in collaboration with Shirley Ryan AbilityLab. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib or placebo. Participants will have an X-ray, knee MRI, brain MRI, blood draws, pain sensitivity testing and will be asked to fill out questionnaires. The purpose of this study is to predict which participants will respond to the treatment.
Age Range
40-99
Clinical Trial