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Cullin E3 ligase activity is required for myoblast differentiation.
Cullin-RING ligases play a pivotal role in proteins disposal and turnover in the cell (think of it like a "spring cleaning" occurring regularly inside the cell). We show that they are essential for skeletal muscle fibers growth and differentiation. A cullin inhibitor, which is also used in cancer therapy, seems to be blocking muscle fiber formation in vitro. Cullin inhibition may have clinical implications for cancer patients in rehabilitation.read more