Welcome to Andrea Domenighetti Biology Lab

Our current research includes the development and implementation of preclinical and translational research projects relevant to muscles rehabilitation in patients with brain or spinal cord injury.
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Our Lab Members

Click the link below to see a list of distinguished students, researchers and scientists that are currently part or have been trained in our Lab.
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Our Projects

Take a look at a few of the projects we work on everyday.

Development of New 3D-Printed Cell Culture Assays for Therapeutic Discovery in Cerebral Palsy and Stroke
PROJECT TYPE: Cerebral Palsy, Stroke, Biology, Cell Biology, Cell Culture, Stem Cells, Muscle, Muscle Fibers, Connective Tissue

Project

Muscle Impairment in Children with Cerebral Palsy: a Role for Muscle Satellite Cells Dysfunction
PROJECT TYPE: Cerebral Palsy, Muscle, Biology, Muscle Fibers, Cell Biology, Stem Cells, Cell Culture

Project

Effect of Inflammation in Hypoxia-Induced Plasticity in Individuals with Spinal Cord Injury
PROJECT TYPE: Spinal Cord Injury, Biology, Cell Biology

Project

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Selected Publications

Cullin E3 ligase activity is required for myoblast differentiation.

Cullin-RING ligases play a pivotal role in proteins disposal and turnover in the cell (think of it like a "spring cleaning" occurring regularly inside the cell). We show that they are essential for skeletal muscle fibers growth and differentiation. A cullin inhibitor, which is also used in cancer therapy, seems to be blocking muscle fiber formation in vitro. Cullin inhibition may have clinical implications for cancer patients in rehabilitation.

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Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association.

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Interested in joining us?

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