Welcome to Dr. Domenighetti's Biology Lab.

Our research group uses tools from molecular biology, cell biology, histology, genetics, experimental and clinical models to translate our understanding of diseases that primarily affect muscles. Our current research includes the development of preclinical and clinical research projects relevant to rehabilitation in patients with neurological or neuromuscular conditions.
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LAB MEMBERS

Click the link below to see a list of distinguished students, researchers and scientists that are currently part or have been trained in our Lab.
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JOB & INTERNSHIP OPPORTUNITIES

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Our Projects

Take a look at a few of the projects we work on everyday.

Defining trajectories of linguistic, cognitive-communicative and quality of life outcomes in aphasia
PROJECT TYPE: Stroke, Aphasia, Quality Improvement, Outcomes, Brain, Biology, Speech Disorders

Research Project

Muscle Impairment in Children with Cerebral Palsy: a Role for Muscle Satellite Cells Dysfunction
PROJECT TYPE: Cerebral Palsy, Muscle, Biology, Muscle Fibers, Cell Biology, Stem Cells, Cell Culture

Research Project

Effect of Inflammation in Hypoxia-Induced Plasticity in Individuals with Spinal Cord Injury
PROJECT TYPE: Spinal Cord Injury, Biology, Cell Biology

Research Project

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Selected Publications

Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy.

Cerebral palsy (CP) is the most common cause of pediatric neurodevelopmental and physical disability in the United States. It is defined as a group of motor disorders caused by a non-progressive perinatal insult to the brain. While the brain lesion is non-progressive, there is a progressive, lifelong impact on skeletal muscles, which are shorter, spastic, and may develop debilitating contractures. Satellite cells are resident muscle stem cells that are indispensable for postnatal growth and…

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Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association.

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Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice.

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Interested in joining us?

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