Pediatric Muscle Physiology Lab
Our research focuses on skeletal muscle mitochondrial function in children with cerebral palsy
read more
Pediatric Muscle Physiology Lab
Our research focuses on the role of muscle stem cells in sarcomere addition and impaired musculoskeletal growth in children with cerebral palsy
read more
Selected Publications
Resident muscle stem cell myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy.
Children with cerebral palsy (CP), a perinatal brain alteration, have impaired postnatal muscle growth, with some muscles developing contractures. Functionally, children are either able to walk or primarily use wheelchairs. Satellite cells are muscle stem cells (MuSCs) required for postnatal development and source of myonuclei. Only MuSC abundance has been previously reported in contractured muscles, with myogenic characteristics assessed only in vitro. We investigated whether MuSC myogenic,…
read more