Translational Cell Therapy Lab
Meet Mitra Lavasani, PhD
Video: The Future of Osteoarthritis
Selected Publications
Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage.
Osteoarthritis (OA) is the most common and debilitating joint disease of advanced age and has no universally effective therapy. Here, we demonstrate that systemic transplantation of adult multipotent muscle-derived stem/progenitor cells (MDSPCs)-isolated from young mice-rejuvenates the knee articular cartilage (AC) of naturally aged mice. This intervention reduced expression of pro-inflammatory cytokines (Tnf and Il1a) and catabolic matrix-degrading proteinases (Mmp3 and Mmp13) in aged…
read moremTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.
read moreBiologic strategies to improve nerve regeneration after peripheral nerve repair.
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Latest Updates
Franz Awarded Falk Catalyst Grant to Restore Diaphragm Function After Cervical Spinal Cord Injury
Colin K. Franz, MD, PhD, has been awarded a Falk Medical Research Trust Catalyst Award to support a new translational research project focused on restoring diaphragm function after high cervical spinal cord injury. The project, titled Accelerating Diaphragm Reinnervation After Spinal Accessory to Phrenic Nerve Transfer Using Human Axon Fusion Technology, addresses a major unmet need in neurorehabilitation and respiratory care.
Regenerative Neurorehabilitation Laboratory Celebrates PhD Graduation of Maria Jose Quezada
The Regenerative Neurorehabilitation Laboratory congratulates Maria Jose “Joe” Quezada, DPT/PhD on the completion of her PhD in Biomedical Engineering at Northwestern University.