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Locomotor Function Following Acute Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation in Individuals with Spinal Cord Injury



The purpose of this study is to determine if acute intermittent hypoxia therapy (AIH) combined with transcutaneous spinal cord stimulation (tSCS) during ambulation training improves locomotor function in individuals with spinal cord injury. This is a randomized, single blind, crossover trial with 3 arms:

  1. AIH + tSCS + gait training
  2. Sham AIH + tSCS + gait training
  3. Sham AIH + Sham tSCS + gait training

Subject Population


  • Diagnosed with a spinal cord injury below level C2 - ASIA Impairment Scale Grade A-D
  • 18 years of age or older
  • At least 6 months post spinal cord injury
  • Paraplegia or tetraplegia secondary to a single spinal cord injury
  • Able to provide informed consent
  • Not currently receiving regular physical therapy services

Study Personnel

Study Partners

Funding Source


Shirley Ryan AbilityLab-Craig H. Nielsen Foundation Infrastructure Grant

Shirley Ryan AbilityLab Catalyst Grant Program

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