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Early Detection and Therapeutic Intervention to Promote Motor Development in Infants



The intervention phase of Project Corbett is a randomized controlled trial to evaluate the efficacy of a one-year long, evidence- and clinical experience-based intervention to improve motor function and reduce the severity of motor delays in infants who have been admitted to a Neonatal Intensive Care Unit (NICU).

Subject Population


NICU admission and qualifies for Early Childhood Clinic (NICU high-risk follow up clinic) or Early Intervention due to:

  • BW <1500 grams


  • Disorders of the central nervous system
    • Brain injury (including but not limited to extra axial hemorrhage, any grade intraventricular or intraparenchymal hemorrhage, stroke, hypoxic ischemic encephalopathy (HIE), meningitis) 
      • HIE includes mild, moderate, severe exam on modified Sarnat exam, both cooled and non-cooled
      • includes “at risk for HIE” with 10-minute Apgar <7 plus pH<7.15 or base deficit >/=12.
    • Brain developmental abnormalities (hydrocephalus, microcephaly, cortical dysgenesis)
    • Cramped synchronous movements at term PMA


  • Bronchopulmonary dysplasia (BPD) defined as need for respiratory support at 36 weeks postmenstrual age in an infant born at <32 weeks of gestation.


  • Medically stable, AND able to start intervention between 34-48 weeks PMA.

Study Personnel

Study Partners


Lurie Children's Hospital

Prentice Women's Hospital

Children's Hospital at the University of Illinois

Funding Source


Patrick G. and Shirley W. Ryan Foundation

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