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Breathing low oxygen to enhance spinal stimulation training and functional recovery in persons with chronic spinal cord injury: The BO2ST Trial



The goal of this double-blind, placebo-controlled, block-randomized clinical trial is to investigate the efficacy and potency of daily acute intermittent hypoxia (AIH) combined with transcutaneous electrical spinal stimulation (tSTIM) and skill-based walking practice. We hypothesize that the combination of AIH, tSTIM, and walking practice will boost the efficacy of training-related gains without triggering maladaptive changes.

Subject Population


  • Age 18 to 70 years
  • Ambulatory incomplete Spinal Cord Injury C2-L2
  • ASIA C or D

Study Personnel

Study Partners


This study is in collaboration with the Inspire Lab led by Dr. Randy Trumbower at Spaulding Rehabilitation Hospital.

Funding Source


Department of Defense

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