Primary Image

tangerine

Clinical Trial

Neuromodulation Clinical Trial

IRB Protocol Number STU00209714

Contact

Reagan Morehouse rmorehouse@sralab.org

Objective

Project Summary

Rehabilitative exercise aims to engage residual neural networks in humans with spinal cord injury to improve functional recovery. In our recent studies, we combined exercise with noninvasive stimulation targeting spinal synapses further promotes functional recovery. In the current protocol, individuals with chronic incomplete spinal cord injury participate 40 sessions of exercise combined with paired corticospinal-motoneuronal stimulation (PCMS). During PCMS, stimuli are timed to have corticospinal volleys evoked by transcranial magnetic stimulation over the primary motor cortex arrive at corticospinal-motoneuronal synapses of upper- and lower-limb muscles before antidromic potentials were elicited in motoneurons by electrical stimulation of peripheral nerve. Participants exercise for about 1 hour after stimulation. Our previous study using similar protocol for 10 sessions showed improvements in physiological and functional outcomes that preserved for at least 6 months after the intervention, which suggests that targeted noninvasive stimulation of spinal synapses might represent an effective strategy to facilitate exercise-mediated recovery in humans with spinal cord injury.

 

Who Can Participate

Anyone with a chronic spinal cord injury (at least 6 months post injury), levels C1-L4.

Compensation

If interested, please reach out to hjo@sralab.org for compensation and study details!

Age Range

18-80

Apply for this Trial

Your information will not be published.

All fields are required.

Featured Quote

Save now, read later.

More Studies Like This

Clinical Research Registry

Sign up here to be enrolled in our contact list for current and future studies that may benefit you and our research around spinal cord injury and stroke.

read more
view all

Latest Updates

view all