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Clinical Trial

Training Hand Muscle Patterns For Stroke Survivors

IRB Protocol Number STU00078099

Contact

Kristen Triandafilou triandafilou@ricres.org

Objective

The purpose of this study is two-fold:

  1. to investigate a new use of an allergy medicine, cyproheptadine (an anti-histaminic and anti-serotonergic agent), to reduce spasticity and muscle hyperexcitability and
  2. to evaluate the effectiveness of a new therapy using active practice of your arm and hand compared to passive stretching.

Based on chance, you will be assigned to one of the four groups

  1. drug and active training
  2. drug and passive stretching
  3. placebo and active training or
  4. placebo and passive stretching.

The investigators hypothesize that the group receiving the combined cyproheptadine and active movement therapy will have better outcomes than the groups receiving cyproheptadine or active movement therapy alone. 

Your involvement will last 13 weeks.  A 13-week study testing a new rehabilitation approach that combines a new occupational therapy with a new drug.  The training will focus on the hand and arm.  The drug dosage will be gradually increased over three weeks and then maintained during 6 weeks (18 sessions) of therapy. Evaluation sessions will occur throughout the study.

Who Can Participate

  • Experienced a single stroke at least 6 months ago
  • Continued impairment in your hand
  • Noticable  tightness in your hand (spasticity)
  • No Botox® injection in your arm within the past 6 months 
  • No history of seizure disorder

Compensation

$20 per training session

$40 per evaluation session

Age Range

Age Range 21 - 80

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